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Start your intake How Tirzepatide and GLP-1 Drugs Affect Your Stomach GLP-1 receptor agonists like tirzepatide work by signaling your brain to feel full and by slowing the rate at which food moves from your stomach into your small intestine
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A GLP-1 agonist (like semaglutide) turns down hunger signals, but GLP-1/GIP receptor agonists improve how the body handles glucose and insulin at the same time, says Niazi
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